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This metabolic roadblock explains why patients with ME/CFS and Long COVID experience such profound, unyielding fatigue

The ceiling reflects observed patterns of progressive insulin resistance, organ-growth concern, and IGF-1 receptor desensitization

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It has also been suggested that the presence of Phascolarctobacterium may be implicated in the development of Hashimotos thyroiditis, althought more research is needed in this space

However, physiological does not mean inevitable